Neoantigens elicit T cell responses in breast cancer

Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in tumour cells. However, their effect on immune responses in the tumour microenvironment remains unclear in breast cancer. We performed whole exome and RNA sequencing of 31 fresh breast cancer tissues and neoantigen p...

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Veröffentlicht in:	Scientific reports 2021-06, Vol.11 (1), p.13590-13590, Article 13590
Hauptverfasser:	Morisaki, Takafumi, Kubo, Makoto, Umebayashi, Masayo, Yew, Poh Yin, Yoshimura, Sachiko, Park, Jae-Hyun, Kiyotani, Kazuma, Kai, Masaya, Yamada, Mai, Oda, Yoshinao, Nakamura, Yusuke, Morisaki, Takashi, Nakamura, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/250 631/67 692/4028 Antigens Breast cancer Cytotoxicity Dendritic cells Enzyme-linked immunosorbent assay Gene expression Histocompatibility antigen HLA Humanities and Social Sciences Lymphocytes Lymphocytes T Microenvironments multidisciplinary Mutation Neoantigens Pleural fluid Pleurisy Science Science (multidisciplinary) Tumor microenvironment Tumors γ-Interferon
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Zusammenfassung:	Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in tumour cells. However, their effect on immune responses in the tumour microenvironment remains unclear in breast cancer. We performed whole exome and RNA sequencing of 31 fresh breast cancer tissues and neoantigen prediction from non-synonymous single nucleotide variants (nsSNVs) among exonic mutations. Neoantigen profiles were determined by predictive HLA binding affinity (IC 50
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-91358-1