Sex-related differences in Cushing's disease: a systematic review and meta-analysis

Cushing's disease is a rare endocrine disorder. This review aimed to examine sex-specific differences in Cushing's disease. A meta-analysis was performed on published articles discussing the gender impact of Cushing's disease. A systematic search was conducted to identify studies from Medline, Embase, CENTRAL and Scopus. Nine studies enrolling 1047 patients diagnosed with Cushing's disease were included in this meta-analysis. Male patients presented at a younger age (MD [mean difference]=-5.43; 95% CI [-5.78, -5.08];