B0-field dependence of MRI T1 relaxation in human brain

B0-field dependence of MRI T1 relaxation in human brain

Tissue longitudinal relaxation characterized by recovery time T1 or rate R1 is a fundamental MRI contrast mechanism that is increasingly being used to study the brain’s myelination patterns in both health and disease. Nevertheless, the quantitative relationship between T1 and myelination, and its de...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2020-06, Vol.213, p.116700-116700, Article 116700
Hauptverfasser: Wang, Yicun, van Gelderen, Peter, de Zwart, Jacco A., Duyn, Jeff H.
Format: Artikel
Sprache:eng
Schlagworte:
B0 field dependence
Brain tissue
Iron concentration
Macromolecular proton fraction
Magnetization transfer
T1 contrast
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Tissue longitudinal relaxation characterized by recovery time T1 or rate R1 is a fundamental MRI contrast mechanism that is increasingly being used to study the brain’s myelination patterns in both health and disease. Nevertheless, the quantitative relationship between T1 and myelination, and its dependence on B0 field strength, is still not well known. It has been theorized that in much of brain tissue, T1 field-dependence is driven by that of macromolecular protons (MP) through a mechanism called magnetization transfer (MT). Despite the explanatory power of this theory and substantial support from in-vitro experiments at low fields (
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2020.116700