Transcriptome analysis of Tetrahymena thermophila response to exposure with dihydroartemisinin

Transcriptome analysis of Tetrahymena thermophila response to exposure with dihydroartemisinin

Dihydroartemisinin (DHA) is a derivative of artemisinin and is toxic to parasites. We used the Tetrahymena thermophila (T. thermophila) as a model to explore DHA toxicity. Results showed that low concentration of DHA (20 μmol/L) promoted cell proliferation, whereas high concentrations of DHA (40–128...

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Veröffentlicht in:Heliyon 2023-03, Vol.9 (3), p.e14069-e14069, Article e14069
Hauptverfasser: Pan, Houjun, Deng, Meiling, Zhang, Bin, Fang, Tiantian, Liu, Yuguo
Format: Artikel
Sprache:eng
Schlagworte:
Dihydroartemisinin
Energy metabolism
Oxidative stress
Tetrahymena thermophila
Toxic effects
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Zusammenfassung:Dihydroartemisinin (DHA) is a derivative of artemisinin and is toxic to parasites. We used the Tetrahymena thermophila (T. thermophila) as a model to explore DHA toxicity. Results showed that low concentration of DHA (20 μmol/L) promoted cell proliferation, whereas high concentrations of DHA (40–1280 μmol/L) inhibited that. Appearance of nucleus was pycnosis by laser scanning confocal microscope. DHA significantly elevated activities of SOD and GSH-Px (P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e14069