Expression of serum microRNAs, mir-182-5p, and miR-590-3p and its clinical significance in neonatal sepsis

Expression of serum microRNAs, mir-182-5p, and miR-590-3p and its clinical significance in neonatal sepsis

Background Neonatal sepsis is one of the life-threatening diseases. MicroRNAs are non-coding RNAs that play vital roles in various diseases. Methods This study included 50 neonates with sepsis and 60 healthy controls. RNA extraction and assessment of mir-182-5p and miR-590-3p using real-time PCR wer...

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Veröffentlicht in:The Gazette of the Egyptian Paediatric Association 2024-12, Vol.72 (1), p.17-9, Article 17
Hauptverfasser: Hamdy, Soha M., Othman, Yomna A., Abdelaleem, Omayma O., Abd El-Hamid, Rehab G., Ali, Doaa Y.
Format: Artikel
Sprache:eng
Schlagworte:
Apgar score
Asphyxia neonatorum
Birth weight
Gestational age
Heart rate
Hemoglobin
Infants (Newborn)
Infection
Laboratories
Males
Medicine
Medicine & Public Health
Methicillin
MicroRNA
MicroRNAs
mir-182-5p
miR-590-3p
Neonatal sepsis
Newborn babies
Pediatrics
Sepsis
Staphylococcus infections
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Zusammenfassung:Background Neonatal sepsis is one of the life-threatening diseases. MicroRNAs are non-coding RNAs that play vital roles in various diseases. Methods This study included 50 neonates with sepsis and 60 healthy controls. RNA extraction and assessment of mir-182-5p and miR-590-3p using real-time PCR were done. Results Significant downregulation of mir-182-5p and miR-590-3p in neonates with sepsis compared with healthy neonates was observed. Positive correlations were confirmed between the expression levels of miR-182-5p and birth weight ( R  = 0.355, P  = 0.012), RDW ( R  = 0.476, p  =  
ISSN:2090-9942
1110-6638
2090-9942
DOI:10.1186/s43054-024-00260-8