Biomarkers for use in monitoring responses of nasopharyngeal carcinoma cells to ionizing radiation

Nasopharyngeal carcinoma (NPC) is a common head and neck cancer. The incidence rate is higher in southern China and Southeast Asia in comparison with the Western countries. Radiotherapy is the standard treatment of NPC as the cancer cells are sensitive to ionizing radiation. Radiation treatment has...

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Veröffentlicht in:	Sensors (Basel, Switzerland) Switzerland), 2012-07, Vol.12 (7), p.8832-8846
Hauptverfasser:	Gao, Wei, Li, John Zenghong, Ho, Wai Kuen, Chan, Jimmy Yuwai, Wong, Thian Sze
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomarkers - metabolism Cancer Carcinoma - metabolism Carcinoma - radiotherapy DNA, Viral - metabolism Gene Expression Regulation HeLa Cells Herpesvirus 4, Human - genetics Histones - metabolism Humans Ionizing radiation MicroRNAs - metabolism Monitoring Monitors nasopharyngeal carcinoma Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - radiotherapy Necks Neoplastic Cells, Circulating - metabolism Patients Positron-Emission Tomography Radiation, Ionizing radiotherapy Review
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Beschreibung
Zusammenfassung:	Nasopharyngeal carcinoma (NPC) is a common head and neck cancer. The incidence rate is higher in southern China and Southeast Asia in comparison with the Western countries. Radiotherapy is the standard treatment of NPC as the cancer cells are sensitive to ionizing radiation. Radiation treatment has good local control to patients with early NPC. It is essential to monitor the response of the NPC cells to radiation treatment in advance in order to select suitable treatment choice for the patients. This review aims to discuss the potential use of biomarkers in monitoring the responsiveness of NPC cells to radiation treatment.
ISSN:	1424-8220 1424-8220
DOI:	10.3390/s120708832