Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats

ResuLts of precLinicaL pharmacodynamic and pharmacokinetic study of tropoxine (a new originaL antimigraine drug) after singLe intravenous administration in rats were presented. Tropoxine in significant extent suppresses constricting reactions of rat brain vesseLs, serotonin, and agonist of 5НТ2В/2С...

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Veröffentlicht in:	Фармакокинетика и Фармакодинамика 2016-09 (3), p.21-25
Hauptverfasser:	V. P. Zherdev, G. B. Kolyvanov, A. A. Litvin, A. A. Novitskyi, T. S. Ganshina, A. A. Gorbunov, R. S. Mirzoyan
Format:	Artikel
Sprache:	rus
Schlagworte:	hplc-ms migraine pharmacokinetics-pharmacodynamics tropoxine высокоэффективная жидкостная хроматография-масс-спектрометрия мигрень тропоксин фармакокинетика-фармакодинамика
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Beschreibung
Zusammenfassung:	ResuLts of precLinicaL pharmacodynamic and pharmacokinetic study of tropoxine (a new originaL antimigraine drug) after singLe intravenous administration in rats were presented. Tropoxine in significant extent suppresses constricting reactions of rat brain vesseLs, serotonin, and agonist of 5НТ2В/2С receptors. Direct reLationship between tropoxine concentrations decreasing in the rat bLood pLasma and changing of the brain circuLation associated with serotonin and m-chLorphenyLpiperazine.
ISSN:	2587-7836 2686-8830