Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent
Eleven novel clerodane-type diterpenoids, grewiifopenes A–K ( 1 – 4 and 12 – 18 ), along with nine known compounds ( 5 – 11 , 19 , and 20 ) were purified from the dichloromethane extract of the twigs and stems of Casearia grewiifolia Vent. (Salicaceae). Their spectroscopic data, including the NMR, H...
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| Veröffentlicht in: | Natural Products and Bioprospecting 2024-12, Vol.14 (1), p.54-19, Article 54 |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
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| Zusammenfassung: | Eleven novel clerodane-type diterpenoids, grewiifopenes A–K (
1
–
4
and
12
–
18
), along with nine known compounds (
5
–
11
,
19
, and
20
) were purified from the dichloromethane extract of the twigs and stems of
Casearia grewiifolia
Vent. (Salicaceae). Their spectroscopic data, including the NMR, HRESIMS, and electronic circular dichroism calculations were employed to completely characterize and elucidate the chemical structures and absolute configurations. The clerodane diterpenoids possessing a 6-OH group and no substitution at C-7 exhibited greater cytotoxic activity than others, with their IC
50
values ranging from 0.3 to 2.9 μM. Isocaseamembrin E (
7
) exhibited antibacterial activity against
Staphylococcus aureus
, while isocaseamembrin E (
7
), corymbulosin X (
8
), caseargrewiin A (
9
), kurzipene A (
10
), and balanspene F (
11
) exhibited antibacterial activity against
Bacillus cereus
.
Graphical Abstract |
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| ISSN: | 2192-2195 2192-2209 |
| DOI: | 10.1007/s13659-024-00475-7 |