Current perspectives in Set7 mediated stem cell differentiation

Current perspectives in Set7 mediated stem cell differentiation

Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimenta...

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Veröffentlicht in:Non-coding RNA 2016-12, Vol.2 (4), p.14
Hauptverfasser: Karimnia, Nazanin, Rafehi, Haloom, Tuano, Natasha K, Ziemann, Mark, K N, Harikrishnan, Okabe, Jun, El-Osta, Assam
Format: Artikel
Sprache:eng
Schlagworte:
Biosynthesis
Cell fate
Communication
Diabetes
Enzymes
Epigenetics
Gene expression
Genomes
histone
Hyperglycemia
Localization
Lysine
Methyltransferase
non-coding RNA
non-histone protein
Peptides
Proteins
Set7
stem cell differentiation
Stem cells
Transcription
Transcription factors
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Zusammenfassung:Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.
ISSN:2311-553X
2311-553X
DOI:10.3390/ncrna2040014