Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA

Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from...

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Veröffentlicht in:	Nature communications 2018-11, Vol.9 (1), p.4568-8, Article 4568
Hauptverfasser:	Gudmundsson, Julius, Sigurdsson, Jon K., Stefansdottir, Lilja, Agnarsson, Bjarni A., Isaksson, Helgi J., Stefansson, Olafur A., Gudjonsson, Sigurjon A., Gudbjartsson, Daniel F., Masson, Gisli, Frigge, Michael L., Stacey, Simon N., Sulem, Patrick, Halldorsson, Gisli H., Tragante, Vinicius, Holm, Hilma, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Jonsson, Thorvaldur, Jonsson, Eirikur, Barkardottir, Rosa B., Hilmarsson, Rafn, Asselbergs, Folkert W., Geirsson, Gudmundur, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Thorleifsson, Gudmar, Stefansson, Kari
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 631/208 631/67 Acetylation Aged Benign Computational Biology Genetic Predisposition to Disease Genital diseases Genome-wide association studies Genome-Wide Association Study Genomes Geriatrics Health risks Histones - metabolism Humanities and Social Sciences Humans Hyperplasia Iceland Lower Urinary Tract Symptoms - blood Lower Urinary Tract Symptoms - genetics Lysine - metabolism Male Meta-Analysis as Topic multidisciplinary Multifactorial Inheritance - genetics Mutation - genetics Older people Phenotype Prostate cancer Prostate-Specific Antigen - blood Prostatic Hyperplasia - blood Prostatic Hyperplasia - genetics Quantitative Trait Loci - genetics Risk Factors Science Science (multidisciplinary) Serum levels United Kingdom Urinary tract
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Zusammenfassung:	Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-018-06920-9