Anti-Cancer and Anti-Inflammatory Activities of Three New Chromone Derivatives from the Marine-Derived Penicillium citrinum

Three new and uncommon chromone analogs, epiremisporine F ( ), epiremisporine G ( ), and epiremisporine H ( ), were isolated from marine-origin . Among the isolated compounds, compounds - remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC values of 31.68 ± 2.53, and 33.52 ± 0.42 μM, respectively. Compound exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC values of 21.17 ± 4.89 and 31.43 ± 3.01 μM, respectively, and Western blot assay confirmed that compound obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.