Circular RNAs as promising biomarkers in cancer: detection, function, and beyond

Circular RNAs as promising biomarkers in cancer: detection, function, and beyond

Circular RNAs (circRNAs) are 3'-5' covalently closed RNA rings produced from back-splicing of precursor mRNA in eukaryotes. Recent studies, using both computational and experimental approaches, have allowed advanced characterization of circRNAs, leading the research field into a new era an...

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Veröffentlicht in:Genome medicine 2019-03, Vol.11 (1), p.15-15, Article 15
Hauptverfasser: Li, Shengli, Han, Leng
Format: Artikel
Sprache:eng
Schlagworte:
Binding sites
Biological markers
Biomarkers
Biomarkers, Tumor - genetics
Biosynthesis
Cancer
Cancer diagnosis
Cancer genetics
Colorectal Neoplasms - genetics
Comment
Computer applications
Gene Expression Regulation, Neoplastic
Genes
Genomes
Humans
Medical research
Messenger RNA
mRNA
Prostate cancer
Proteins
RNA
RNA, Circular - genetics
Splicing
Transcription factors
Trends
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Beschreibung
Zusammenfassung:Circular RNAs (circRNAs) are 3'-5' covalently closed RNA rings produced from back-splicing of precursor mRNA in eukaryotes. Recent studies, using both computational and experimental approaches, have allowed advanced characterization of circRNAs, leading the research field into a new era and shedding light on the contribution of circRNAs to disease.
ISSN:1756-994X
1756-994X
DOI:10.1186/s13073-019-0629-7