Are Women with Normal-Weight Obesity at Higher Risk for Cardiometabolic Disorders?

This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. This cross-sectional study evaluated the assessment of cardiometabolic abnormalities of women with NWO compared to lean, overweight, and obes...

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Veröffentlicht in:Biomedicines 2023-01, Vol.11 (2), p.341
Hauptverfasser: Ashtary-Larky, Damoon, Niknam, Sara, Alipour, Meysam, Bagheri, Reza, Asbaghi, Omid, Mohammadian, Mehrnaz, Jaime, Salvador J, Baker, Julien S, Wong, Alexei, Suzuki, Katsuhiko, Afrisham, Reza
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Sprache:eng
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Zusammenfassung:This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. This cross-sectional study evaluated the assessment of cardiometabolic abnormalities of women with NWO compared to lean, overweight, and obese women. NWO was defined as a BMI < 25 kg.m and a BFP higher than 30%. Anthropometric variables, cardiometabolic abnormality markers (fasting blood glucose (FBG), blood pressure (BP), lipid profile, insulin resistance, and high-sensitivity C-reactive protein (hs-CRP)), and liver enzymes were also examined. Significant differences were observed in HDL concentrations between NWO, lean, and obese participants ( < 0.05). There were no significant differences in FBG, insulin resistance, liver enzymes, or cholesterol between groups ( > 0.05). The prevalence of the abnormal metabolic phenotype was higher in NWO compared to the lean group (4.0% and 24.1%, respectively; < 0.05). Women with type 2 and 3 obesity had abnormal metabolic profiles (60.9% and 73.9%, respectively) compared to NWO participants ( < 0.01). The NWO group had a significantly higher incidence of cardiometabolic abnormalities compared to the lean participants ( < 0.05), while the type 2 and 3 obese individuals had significantly higher incidences compared to the NWO group ( < 0.001 and < 0.001, respectively). Individuals with NWO had a significantly higher incidence of cardiometabolic abnormalities when compared to lean participants. These abnormalities strongly relate to BFP and waist circumferences.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11020341