Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological prop...

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Veröffentlicht in:Acta pharmaceutica Sinica. B 2014-10, Vol.4 (5), p.358-367
Hauptverfasser: Boligon, Aline Augusti, de Freitas, Robson Borba, de Brum, Thiele Faccim, Waczuk, Emily Pansera, Klimaczewski, Cláudia Vargas, de Ávila, Daiana Silva, Athayde, Margareth Linde, de Freitas Bauermann, Liliane
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidant
Gastric ulcer
HPLC
Original
Scutia buxifolia
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Beschreibung
Zusammenfassung:Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2014.05.001