Manipulation of Macrophages: Emerging Mechanisms of Leishmaniasis

As professional phagocytes, macrophages represent the first line of defence against invading microbial pathogens. Various cellular processes such as programmed cell death, autophagy and RNA interference (RNAi) of macrophages are involved directly in elimination or assist in elimination of invading pathogens. However, parasites, such as , have evolved diverse strategies to interfere with macrophage cell functions, favouring their survival, growth and replication inside hostile and restrictive environments of macrophages. Therefore, identification and detailed characterization of macrophage-pathogen interactions is the key to understanding how pathogens subvert macrophage functions to support their infection and disease process. In recent years, great progress has been achieved in understanding how affects with critical host macrophage functions. Based on latest progress and accumulating knowledge, this review exclusively focuses on macrophage- interaction, providing an overview of macrophage cellular processes such as programmed cell death, autophagy and RNAi during infection. Despite extensive progress, many questions remain and require further investigation.