Polyketide Derivatives from the Mangrove-Derived Fungus Penicillium sp. HDN15-312

Four new polyketides, namely furantides A-B ( - ), talamin E ( ) and arugosinacid A ( ), and two known polyketides were obtained from the mangrove-derived fungus sp. HDN15-312 using the One Strain Many Compounds (OSMAC) strategy. Their chemical structures, including configurations, were elucidated b...

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Veröffentlicht in:	Marine drugs 2024-08, Vol.22 (8), p.360
Hauptverfasser:	Liu, Fuhao, Wang, Wenxue, Wang, Feifei, Zhou, Luning, Luo, Guangyuan, Zhang, Guojian, Zhu, Tianjiao, Che, Qian, Li, Dehai
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Ascorbic acid Biphenyl Compounds Carbon Cellular signal transduction DPPH Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Fungi Magnetic Resonance Spectroscopy Mangroves Metabolites Molecular Structure NMR Nuclear magnetic resonance OSMAC Oxidative stress Penicillium Penicillium - chemistry Penicillium sp Physiological aspects Picrates Polyketides Polyketides - chemistry Polyketides - isolation & purification Polyketides - pharmacology Rhizophoraceae - microbiology Scavenging theoretical calculations Vitamin C
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Zusammenfassung:	Four new polyketides, namely furantides A-B ( - ), talamin E ( ) and arugosinacid A ( ), and two known polyketides were obtained from the mangrove-derived fungus sp. HDN15-312 using the One Strain Many Compounds (OSMAC) strategy. Their chemical structures, including configurations, were elucidated by detailed analysis of extensive NMR spectra, HRESIMS and ECD. The DPPH radicals scavenging activity of , with an IC value of 6.79 µM, was better than vitamin C.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md22080360