Increased Excretion of Urinary 20-HETE in Rats With Cyclosporine-Induced Nephrotoxicity

Increased Excretion of Urinary 20-HETE in Rats With Cyclosporine-Induced Nephrotoxicity

The present study examined the contribution of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) in cyclosporine A (CsA)-induced renal nephrotoxicity. Treatment of rats with CsA (50 mg/kg) for 9 days induced renal damage as indicated by marked increase in urine flow (from 9.0 ± 0.3 ml/day to 46.6...

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Veröffentlicht in:Journal of Pharmacological Sciences 2005, Vol.97(1), pp.132-137
Hauptverfasser: Seki, Takayuki, Ishimoto, Tsuyoshi, Sakurai, Takanobu, Yasuda, Yoshiko, Taniguchi, Kazuo, Doi, Mariko, Sato, Mariko, Roman, Richard J., Miyata, Noriyuki
Format: Artikel
Sprache:eng
Schlagworte:
20-HETE
Animals
Blood
Blood Urea Nitrogen
Creatinine - blood
Cyclosporine - adverse effects
Cyclosporine - metabolism
Cyclosporine - therapeutic use
cyclosporine A
Cyclosporins
Cytochrome P-450 CYP4A - chemistry
Cytochrome P-450 CYP4A - drug effects
Cytochrome P-450 CYP4A - genetics
Cytochrome P450
cytochrome P450 4A
Drug Administration Schedule
Excretion
Gene Expression - drug effects
Gene Expression - genetics
Hydroxyeicosatetraenoic Acids - adverse effects
Hydroxyeicosatetraenoic Acids - urine
Injections, Intraperitoneal
Kidney
Kidney Cortex - drug effects
Kidney Cortex - metabolism
Kidney Cortex - ultrastructure
Kidney Diseases - chemically induced
Kidney Diseases - urine
Male
nephrotoxicity
Nitrogen
Proximal tubules
Rats
Rats, Sprague-Dawley
renal injury
Time Factors
Urea
Urine
Urine - chemistry
Urine - physiology
Urodynamics - drug effects
Urodynamics - physiology
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Zusammenfassung:The present study examined the contribution of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) in cyclosporine A (CsA)-induced renal nephrotoxicity. Treatment of rats with CsA (50 mg/kg) for 9 days induced renal damage as indicated by marked increase in urine flow (from 9.0 ± 0.3 ml/day to 46.6 ± 7.1 ml/day) and a 3 – 5-fold rise in blood urea nitrogen (BUN) levels. The urinary excretion of 20-HETE increased from 164 ± 5 ng/day (N = 5) to 2432 ± 290 ng/day (N = 5, P
ISSN:1347-8613
1347-8648
1347-8648
DOI:10.1254/jphs.fp0040574