Clinical Features of Hepatic Cirrhosis in Hypopituitarism

Background Hepatic cirrhosis represents the final stage for a wide variety of chronic liver diseases, which may be induced by numerous causes, and is associated with high mortality when complications arise. The relationships between hormone deficiencies due to hypopituitarism and hepatic cirrhosis have been rarely reported. Objective To analyze the clinical characteristics of 8 cases of hepatic cirrhosis secondary to hypopituitarism, and investigate the potential role of hypopituitarism in the development of hepatic cirrhosis. Methods Participants were 8 patients with hepatic cirrhosis secondary to hypopituitarism who were recruited from the First Affiliated Hospital of Zhengzhou University from January 2010 to December 2021. A retrospective analysis was conducted on their clinical manifestations, laboratory and imaging test result, treatments and follow-up results. Results The age at the diagnosis of hypopituitarism for all cases ranged from 9 to 20 years old, and that at the diagnosis of hepatic cirrhosis w