H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy

Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer, including breast,...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2019-05, Vol.8 (5), p.485
Hauptverfasser:	Hałasa, Marta, Wawruszak, Anna, Przybyszewska, Alicja, Jaruga, Anna, Guz, Małgorzata, Kałafut, Joanna, Stepulak, Andrzej, Cybulski, Marek
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation - drug effects Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - metabolism Breast cancer cancer hallmarks Cancer therapies Carcinogenesis Cell Line, Tumor Chromatin remodeling Colon Colon cancer Cyclin-dependent kinases Deacetylation Disease Progression Disease-Free Survival DNA methylation Epigenetics Gene expression H3K18Ac HATs HDACs histone acetylation histone deacetylation Histones Histones - antagonists & inhibitors Histones - metabolism Humans Kinases Localization Lung cancer Lysine Male Mice Mutation Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Pancreas Pancreatic cancer Progression-Free Survival Prostate cancer Protein Processing, Post-Translational Proteins Review Signal transduction Thyroid cancer Tumor cell lines
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Zusammenfassung:	Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer, including breast, colon, lung, hepatocellular, pancreatic, prostate, and thyroid cancer. The aim of this review is to analyze and discuss the newest findings regarding the role of H3K18Ac and acetylation of other histones in carcinogenesis. We summarize the level of H3K18Ac in different cancer cell lines and analyze its association with patients' outcomes, including overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS). Finally, we describe future perspectives of cancer therapeutic strategies based on H3K18 modifications.
ISSN:	2073-4409 2073-4409
DOI:	10.3390/cells8050485