1-(4-Chlorophenyl)-2-methyl-2-phenyl-5-(thiophen-2-yl)-1,2-dihydro-3H-pyrrol-3-one

1-(4-Chlorophenyl)-2-methyl-2-phenyl-5-(thiophen-2-yl)-1,2-dihydro-3H-pyrrol-3-one

1-(4-Chlorophenyl)-2-methyl-2-phenyl-5-(thiophen-2-yl)-1,2-dihydro-3H-pyrrol-3-one, was synthesized for the first time in 75% yield by the base-catalyzed intramolecular cyclization of 4-((4-chlorophenyl)amino)-4-phenyl-1-(thiophen-2-yl)pent-2-yn-1-one. The starting aminoacetylenic ketone was prepare...

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Veröffentlicht in:MolBank 2022-12, Vol.2022 (4), p.M1520
Hauptverfasser: Volkov, Pavel A., Khrapova, Kseniya O., Telezhkin, Anton A., Bidusenko, Ivan A., Albanov, Alexander I., Trofimov, Boris A.
Format: Artikel
Sprache:eng
Schlagworte:
3H-pyrrol-3-one
aminoacetylenic ketones
Chromatography
Conflicts of interest
Correlation analysis
Cross coupling
cyclization
electron-deficient acetylenes
Ketones
Spectrum analysis
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Zusammenfassung:1-(4-Chlorophenyl)-2-methyl-2-phenyl-5-(thiophen-2-yl)-1,2-dihydro-3H-pyrrol-3-one, was synthesized for the first time in 75% yield by the base-catalyzed intramolecular cyclization of 4-((4-chlorophenyl)amino)-4-phenyl-1-(thiophen-2-yl)pent-2-yn-1-one. The starting aminoacetylenic ketone was prepared by cross-coupling of available propargylamines with acyl chlorides in the presence of the PdCl2/CuI/Ph3P catalytic system.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1520