Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2016-03, Vol.7 (1), p.10933-9, Article 10933
Hauptverfasser:	Berndt, Sonja I., Skibola, Christine F., Vijai, Joseph, Wang, Zhaoming, Kelly, Rachel S., Smedby, Karin E., Cozen, Wendy, Wang, Sophia S., Lan, Qing, Teras, Lauren R., Machado, Moara, Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Vajdic, Claire M., Cocco, Pierluigi, Zhang, Yawei, Giles, Graham G., Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Montalvan, Rebecca, Hutchinson, Amy, Ye, Yuanqing, Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Cunningham, Julie M., Allmer, Cristine, Hjalgrim, Henrik, Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Diver, W Ryan, Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Arnett, Donna K., Leach, Justin M., Holly, Elizabeth A., Benavente, Yolanda, Sala, Núria, Casabonne, Delphine, Becker, Nikolaus, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Chaffee, Kari G., Achenbach, Sara J., Strom, Sara S., Leis, Jose F., Caporaso, Neil E., De Roos, Anneclaire J., Severson, Richard K., Kaaks, Rudolph, Weiderpass, Elisabete, Chirlaque, María- Dolores, Vermeulen, Roel C. H., Travis, Ruth C., Southey, Melissa C., Milne, Roger L., Albanes, Demetrius, Zheng, Tongzhang, Holford, Theodore R., Maria, Ann, Gascoyne, Randy D., Connors, Joseph M., Bertrand, Kimberly A., Giovannucci, Edward, Kraft, Peter, Kricker, Anne, Turner, Jenny, Ennas, Maria Grazia, Miligi, Lucia, Liang, Liming, Ma, Baoshan, Crouch, Simon, Park, Ju-Hyun, Chatterjee, Nilanjan, North, Kari E., Snowden, John A., Wright, Josh, Fraumeni, Joseph F., Offit, Kenneth, Wu, Xifeng, de Sanjose, Silvia, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Slager, Susan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205/2138 631/208/68 631/67/1990/283/1895 631/80/82/23 Adaptor Proteins, Signal Transducing - genetics Agent Orange Apoptosis Apoptosis Regulatory Proteins - genetics Bcl-2-Like Protein 11 Chromosome 2 Chromosome 3 Chromosome 4 Chronic lymphocytic leukemia Community medicine, Social medicine: 801 Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Health sciences: 800 Helsefag: 800 Hematology Heritability Human health and pathology Humanities and Social Sciences Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Life Sciences Loci Lymphatic leukemia Malignancy Medical disciplines: 700 Medisinske Fag: 700 Membrane Proteins - genetics Meta-analysis multidisciplinary Polymorphism, Single Nucleotide Proto-Oncogene Proteins - genetics Samfunnsmedisin, sosialmedisin: 801 Science Science (multidisciplinary) Serpins - genetics Single-nucleotide polymorphism T-Box Domain Proteins - genetics VDP White People - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES , P =2.55 × 10 −11 ), 6p25.2 (rs73718779, SERPINB6 , P =1.97 × 10 −8 ) and 3q28 (rs9815073, LPP , P =3.62 × 10 −8 ), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11 , P =1.00 × 10 −11 ) in the combined analysis. We find suggestive evidence ( P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms10933