Replication of Novel Zoonotic-Like Influenza A(H3N8) Virus in Ex Vivo Human Bronchus and Lung

Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication efficiency in bronchial and lung tissue but had a higher replication than avian H3N8 vir...

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Veröffentlicht in:	Emerging infectious diseases 2023-06, Vol.29 (6), p.1210-1214
Hauptverfasser:	Hui, Kenrie P Y, Ho, John C W, Ng, Ka-Chun, Cheng, Samuel M S, Sit, Ko-Yung, Au, Timmy W K, Poon, Leo L M, Nicholls, John M, Peiris, Malik, Chan, Michael C W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Animals Antigens Avian flu Avian influenza Avian influenza viruses Birds Bronchi Causes of Development and progression Disease Dispatch Genes H3N8 Health aspects human bronchus human lung Humans Identification and classification Infections influenza influenza A virus Influenza A Virus, H3N8 Subtype Influenza, Human Lung - diagnostic imaging Lungs Mutation Orthomyxoviridae Infections Physiological aspects Poultry Respiratory distress syndrome risk assessment Virus Replication Virus research Viruses Zoonoses
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Zusammenfassung:	Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication efficiency in bronchial and lung tissue but had a higher replication than avian H3N8 virus in lung tissue.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2906.221680