SRXN1 blood levels negatively correlate with hippocampal atrophy and cognitive decline [version 1; peer review: 2 approved]

Introduction : Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods : In this cross-sectional study, we examined how cognitive decline and hippocampal subfields v...

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Veröffentlicht in:	F1000 research 2022, Vol.11, p.114
Hauptverfasser:	Cucos, Catalina Anca, Cracana, Ioana, Dobre, Maria, Popescu, Bogdan Ovidiu, Tudose, Catalina, Spiru, Luiza, Manda, Gina, Niculescu, Gabriela, Milanesi, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrophy - pathology blood Cognitive decline Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - genetics Cognitive Dysfunction - pathology Cross-Sectional Studies eng Hippocampus - diagnostic imaging Humans Magnetic Resonance Imaging MRI Neurodegenerative Diseases RNA, Messenger - genetics SRXN1
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Zusammenfassung:	Introduction : Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods : In this cross-sectional study, we examined how cognitive decline and hippocampal subfields volume are associated with the expression of redox and inflammatory genes in peripheral blood. We analyzed 34 individuals with different cognitive scores according to Mini-Mental State Examination, corrected by age and education (adjMMSE). We identified a group presenting cognitive decline (CD) with adjMMSE
ISSN:	2046-1402 2046-1402
DOI:	10.12688/f1000research.76191.1