Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China

The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum effiux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β-naphthylamide (PAL3N), on the contribution of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of Integrative Agriculture 2016-04, Vol.15 (4), p.929-933
Hauptverfasser: LI, Ya-fei, JIANG, Hong-xia, XIANG, Rong, SUN, Na, ZHANG, Ya-nan, ZHAO, Li-qing, GU, Peng, WANG, Li-qiao, ZENG, Zhen-ling
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum effiux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β-naphthylamide (PAL3N), on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftdaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestiferisolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates.
ISSN:2095-3119
2352-3425
DOI:10.1016/S2095-3119(15)61031-0