Discovery of novel diterpenoids from Sinularia arborea

Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of...

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Veröffentlicht in:	Marine drugs 2014-01, Vol.12 (1), p.385-393
Hauptverfasser:	Chen, Kuan-Hua, Dai, Chang-Feng, Hwang, Tsong-Long, Chen, Chun-Yu, Li, Jan-Jung, Chen, Jih-Jung, Wu, Yang-Chang, Sheu, Jyh-Horng, Wang, Wei-Hsien, Sung, Ping-Jyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthozoa - chemistry Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoid Magnetic Resonance Spectroscopy Marine Models, Molecular Molecular Conformation sinularbol sinularborane Sinularia Sinularia arborea Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared superoxide anion Superoxides - chemistry
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Zusammenfassung:	Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of superoxide anion by human neutrophils.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md12010385