Significance of transcription factor LMO3 in evaluating prognosis of patients with endometrial carcinoma

Objective To investigate the significance of transcription factor LIM domain only 3 (LMO3) expression level in the prognosis of patients with endometrial carcinoma (EC). Methods The Cancer Genome Atlas (TCGA), GeneMANIA and STRING databases were used to analyze the relationship between LMO3 expression in EC tissues and the prognosis of patients, as well as the genes interacting with LMO3, and the correlation of LMO3 with TP53 mutation. The paraffin sections and clinical information of 51 patients with EC who underwent surgery in our hospital from March 2011 to December 2014 were collected. Immunohistochemical staining was subsequently performed to determine the expression of LMO3 in EC tissues and its association with the clinicopathological features of patients. SPSS was used to plot the survival curve, and COX multivariate regression analysis was also adopted. In addition, LMO3 overexpression was conducted in EC cells to verify its effect on tumor cell migration. Results According to the analysis of TCGA da