HIV and CKD in the Tenofovir Era: A Prospective Parallel-Group Cohort Study From Tanzania

Longitudinal research on chronic kidney disease (CKD) in sub-Saharan Africa is sparse, especially among people living with HIV (PLWH). We evaluated the incidence of CKD among PLWH compared with HIV-uninfected controls in Tanzania. Prospective cohort study. A total of 495 newly diagnosed PLWH who initiated antiretroviral therapy (ART) and 505 HIV-uninfected adults enrolled from public HIV clinics and followed from 2016-2021. The control group was recruited from HIV treatment partners from the same HIV clinics. Untreated HIV (at baseline), ART, sociodemographic information, health behaviors, hypertension, and diabetes. Incident CKD, defined as a follow-up estimated glomerular filtration rate (eGFR) of