Sex-specific Analysis of Influencing Factors for the Association between Baseline Serum Uric Acid and Two-year Outcome after First Acute Ischemic Stroke

Background The level of serum uric acid (SUA) has recently been proven to be associated with outcomes in patients with acute ischemic stroke (AIS) , but whether the association is still controversial. Objective To explore the relationship of baseline SUA level with two-year recurrence and all-cause mortality after first AIS. Methods This retrospective study was conducted with a cohort of inpatients with first AIS treated in Department of Neurology, University of Hong Kong-Shenzhen Hospital from January 1, 2018 to December 31, 2019. The general information, biochemical indicators, and two-year adverse outcome (recurrence and all-cause mortality) after first AIS were collected and a follow up until December 31, 2021. Logistic regression analysis was used to explore the relationship of adverse outcome with quartile of baseline SUA levels〔Q1 group (n=129) , Q2 group (n=129) , Q3 group (n=128) , Q4 group (n=127) 〕 by sex. Results Univariate Logistic regression analysis showed that advanced age, history of diabetes