Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis
To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. A transcriptome-wide association study (TWAS) was conducted by the FUSION software for RA considering EBV-transformed lymphocy...
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Veröffentlicht in: | Arthritis research & therapy 2021-01, Vol.23 (1), p.38-38, Article 38 |
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Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data.
A transcriptome-wide association study (TWAS) was conducted by the FUSION software for RA considering EBV-transformed lymphocytes (EL), transformed fibroblasts (TF), peripheral blood (NBL), and whole blood (YBL). GWAS summary data was driven from a large-scale GWAS, involving 5539 autoantibody-positive RA patients and 20,169 controls. The TWAS-identified genes were further validated using the mRNA expression profiles and made a functional exploration.
TWAS identified 692 genes with P
values |
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ISSN: | 1478-6362 1478-6354 1478-6362 |
DOI: | 10.1186/s13075-021-02419-9 |