Use of zebrafish to study Shigella infection
is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore biology; however, we still la...
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Veröffentlicht in: | Disease models & mechanisms 2018-02, Vol.11 (2) |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year.
is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore
biology; however, we still lack information regarding the events taking place during the
infection process
Here, we discuss a selection of mechanistic insights recently gained from studying
infection of zebrafish (
), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how
infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans. |
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ISSN: | 1754-8403 1754-8411 |
DOI: | 10.1242/dmm.032151 |