Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited

Gene mutations in the virulence regulator CovR/S of group A Streptococcus play a substantial role in the pathogenesis of streptococcal toxic shock syndrome. We screened 25 group B Streptococcus (GBS) isolates obtained from patients with streptococcal toxic shock syndrome and found only 1 GBS clone h...

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Veröffentlicht in:	Emerging infectious diseases 2017-01, Vol.23 (1), p.150-152
Hauptverfasser:	Sendi, Parham, El Hay, Muad Abd, Brandt, Claudia M, Spellerberg, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Female Gene Expression Regulation, Bacterial Gene mutation Genetic aspects Group B Streptococcal Toxic Shock Syndrome and group B Streptococcus Humans Infant, Newborn Letter Letters to the Editor Male Middle Aged Multilocus Sequence Typing Mutation Mutations Revisited Repressor Proteins - genetics Repressor Proteins - metabolism Serotyping Shock, Septic - microbiology Shock, Septic - mortality Shock, Septic - pathology Streptococcal Infections - microbiology Streptococcal Infections - mortality Streptococcal Infections - pathology streptococcal toxic shock syndrome streptococci Streptococcus agalactiae - classification Streptococcus agalactiae - genetics Streptococcus agalactiae - pathogenicity Survival Analysis Toxic shock syndrome two-component system Virulence Virulence (Microbiology) Virulence Factors - genetics Virulence Factors - metabolism
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Zusammenfassung:	Gene mutations in the virulence regulator CovR/S of group A Streptococcus play a substantial role in the pathogenesis of streptococcal toxic shock syndrome. We screened 25 group B Streptococcus (GBS) isolates obtained from patients with streptococcal toxic shock syndrome and found only 1 GBS clone harboring this kind of mutation.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2301.161063