Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies

Inflammation and B-cell hyperactivation have been associated with non-Hodgkin lymphoma development. This prospective analysis aimed to further elucidate pre-diagnosis plasma immune marker profiles associated with non-Hodgkin lymphoma risk. We identified 598 incident lymphoma cases and 601 matched co...

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Veröffentlicht in:Haematologica (Roma) 2018-10, Vol.103 (10), p.1679-1687
Hauptverfasser: Epstein, Mara M, Rosner, Bernard, Breen, Elizabeth C, Batista, Julie L, Giovannucci, Edward L, Magpantay, Larry, Aster, Jon C, Rodig, Scott J, Bertrand, Kimberly A, Laden, Francine, Martínez-Maza, Otoniel, Birmann, Brenda M
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Sprache:eng
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Zusammenfassung:Inflammation and B-cell hyperactivation have been associated with non-Hodgkin lymphoma development. This prospective analysis aimed to further elucidate pre-diagnosis plasma immune marker profiles associated with non-Hodgkin lymphoma risk. We identified 598 incident lymphoma cases and 601 matched controls in Nurses' Health Study and Health Professionals Follow-up Study participants with archived pre-diagnosis plasma samples and measured 13 immune marker levels with multiplexed immunoassays. Using multivariable logistic regression we calculated Odds Ratios (OR) and 95% Confidence Intervals (CI) per standard deviation unit increase in biomarker concentration for risk of non-Hodgkin lymphoma and major histological subtype, stratifying additional models by years (
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2017.183236