Gold-Catalyzed Propargylic Substitution Followed by Cycloisomerization in Ionic Liquid: Environmentally Friendly Synthesis of Polysubstituted Furans from Propargylic Alcohols and 1,3-Dicarbonyl Compounds

Gold-Catalyzed Propargylic Substitution Followed by Cycloisomerization in Ionic Liquid: Environmentally Friendly Synthesis of Polysubstituted Furans from Propargylic Alcohols and 1,3-Dicarbonyl Compounds

Gold-catalyzed propargylic substitution of propargylic alcohols with 1,3-dicarbonyl compounds followed by cycloisomerization in ionic liquid enables the environmentally friendly synthesis of polysubstituted furans in good-to-high yields. The reaction proceeds via the hydrated propargylic substitutio...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2024-11, Vol.29 (22), p.5441
Hauptverfasser: Chiaki, Hitomi, Hashimoto, Yoshimitsu, Morita, Nobuyoshi
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
Alcohols
Chemical synthesis
Chemical tests and reagents
cycloisomerization
Furans
Gold
gold catalyst
ionic liquid
propargylic substitution
Reagents
Solvents
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Zusammenfassung:Gold-catalyzed propargylic substitution of propargylic alcohols with 1,3-dicarbonyl compounds followed by cycloisomerization in ionic liquid enables the environmentally friendly synthesis of polysubstituted furans in good-to-high yields. The reaction proceeds via the hydrated propargylic substitution product . The gold catalyst can be recycled at least three times.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29225441