Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context

Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context

Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of hepatocellular carcinoma. We found that the rate of R70Q/H in HCV 1b from Russia was 31.2%, similar to that in HCV strains from Asia (34.0%), highe...

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Veröffentlicht in:Journal of Immunology Research 2018-01, Vol.2018 (2018), p.1-13
Hauptverfasser: Mikhaylov, Mikhail I., Isaeva, O. V., Karlsen, A. A., Soboleva, N. V., Kyuregyan, K. K., Kichatova, V. S., Isaguliants, Maria
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Cell recognition
Core protein
Epitopes
Evolution & development
Gastroenterology
Genomes
Genotype & phenotype
Hepatitis
Hepatocellular carcinoma
Hepatology
Histocompatibility antigen HLA
Immunology
Infections
Interferon
Liver cancer
Liver diseases
Lymphocytes T
Mutation
Peptides
Proteins
R&D
Research & development
Studies
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Zusammenfassung:Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of hepatocellular carcinoma. We found that the rate of R70Q/H in HCV 1b from Russia was 31.2%, similar to that in HCV strains from Asia (34.0%), higher than that in the European (18.0%, p=0.0010), but lower than that in the US HCV 1b strains (62.8%, p
ISSN:2314-8861
2314-7156
DOI:10.1155/2018/7685371