Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures

The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing in the pharmaceutical industry, blending of excipients and API is converted to a continuous process. The relation between material properties and blend homogeneity, however, is generally based on batch-wise blending trials. Limited information is available on how material properties affect blending performance in a continuous process. Here, blending of API and excipients is studied in both a batch and a continuous process. Homogeneity of the resulting mixtures is analyzed, which reveals that the impact of material properties is very different in a continuous process. Where parameters such as particle size, density and flowability have significant impact on blending performance in a traditional batch process, continuous blending is more robust resulting in uniform blends for a large variety of blend compositions. [Display omitted] •Continuous mixing improves blend uniformity of pharmaceutical powder mixtures.•Blend uniformity is highly dependent on excipient properties in a batch process.•Continuous mixing is more robust, with little impact of material properties.•Powder bulk density strongly affects blend homogeneity in a batch process.•Blending of low API dosages is more challenging in a continuous process.