T follicular helper cells and antibody response to Hepatitis B virus vaccine in HIV-1 infected children receiving ART

HBV vaccine has 95% efficacy in children to prevent HBV infection and related cancer. We conducted a prospective study in HIV-1 infected children receiving ART (n = 49) and controls (n = 63) to assess humoral and cellular responses to HBV vaccine provided with three doses under an accelerated schedu...

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Veröffentlicht in:	Scientific reports 2017-08, Vol.7 (1), p.8956-11, Article 8956
Hauptverfasser:	Bekele, Yonas, Yibeltal, Desalegn, Bobosha, Kidist, Andargie, Temesgen E., Lemma, Mahlet, Gebre, Meseret, Mekonnen, Eyasu, Habtewold, Abiy, Nilsson, Anna, Aseffa, Abraham, Howe, Rawleigh, Chiodi, Francesca
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/21 13/31 631/250/590 692/308/575 Antibody response Antiretroviral drugs Cancer Children CXCL13 protein Helper cells Hepatitis B Humanities and Social Sciences Immunization multidisciplinary Plasma levels Public health Science Science (multidisciplinary) Vaccination Vaccines
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Beschreibung
Zusammenfassung:	HBV vaccine has 95% efficacy in children to prevent HBV infection and related cancer. We conducted a prospective study in HIV-1 infected children receiving ART (n = 49) and controls (n = 63) to assess humoral and cellular responses to HBV vaccine provided with three doses under an accelerated schedule of 4 weeks apart. At 1 month post-vaccination all children, except 4 HIV-1 infected, displayed protective antibody (ab) titers to HBV vaccine; ab titers were lower in infected children (P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-017-09165-6