Editorial: Biology of Brain Disorders

There is a reliance on cellular models, cell lines, primary cells, and stem cells and model organisms, from flies to rodents, to gain invasive and fundamental insights not possible in human experiments. MRI is of particular value as it one of a few tools that may be used both in the clinic and in animal experiments and can therefore provide a translational framework for the combination of model organisms with multimodal imaging and other modalities such as EEG, behavior and post-mortem cell and molecular analysis to elucidate mechanisms underlying imaging phenomena in patients with brain disorders (McIntosh et al.). [...]progress will no doubt be related to technological advances in molecular screening and detection, the manipulation and study of neuronal circuits, tools for assessment of systems/regional connectivity, and whole brain function which may be used in both animal and human experiments and the analysis of big data drawn from multi-centered strategic partnerships in the development of projects of greater scale.