AdjuvareDB: A comprehensive database for candidate adjuvant compendium in clinic

The detailed information of adjuvants can be detected via the browse screen, mainly including protein-based adjuvant-related gene symbol, the detailed annotation, application in related diseases, source literatures, ingredients, and other information (Figure 4). SEE PDF] To provide landscapes of collected genetic adjuvants at different molecular levels that may contribute to understanding the potential molecular features in cancer, the analysis module provides the primary analysis based on integrated mRNA expression data, mutation data, DNA methylation data, copy number variation data and related clinical information (Figure S1). Compared to similar efforts (such as the Vaxjo8 and Vaccine Adjuvant Compendium), we mainly extract and collate supportive literatures through text mining, but we also focus more on the potential application of adjuvants in cancer immunotherapy, providing researchers with a platform of potential adjuvant data through analysis modules and clinical trials acquisition (Figure 1). FUNDING INFORMATION This work was supported by National Natural Science Foundation of China (62171236), the key project of social development in Jiangsu Province (BE2022799), the key projects of Natural Science Research in Universities of Jiangsu Province (22KJA180006), the Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University (SKLB2022-K03), funding from Shandong Provincial Key Laboratory of Biophysics, Postgraduate Research & Practice Innovation Program of Jiangsu Province, and the Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD).