Design and Synthesis of Some New Quinoline Based 1,2,3-Triazoles as Antimicrobial and Antimalarial Agents

A series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinohne and its derivatives (5a-j) were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin -3-yl)methanol (2), methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate (3) and 3-azidomethyl-6-bromo-2-chloro-quinoline (4). The synthetic route leading to the title compounds is commenced from commercially available 6-bromo-2-chloro-quinolin-3-carbaldehyde (1). The chemical structures of the newly synthesized compounds were elucidated by their IR, [sup.1]H and [sup.13]C NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial activity against various microorganisms and antimalarial activity towards P. falciparum. Keywords: quinolone; triazoles; antimicrobial activity; antimalarial