Experimental models of Schistosoma mansoni infection

Experimental models of Schistosoma mansoni infections in mammals have contributed greatly to our understanding of the pathology and pathogenesis of infection. We consider here hepatic and extrahepatic disease in models of acute and chronic infection. Experimental schistosome infections have also con...

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Veröffentlicht in:	Memórias do Instituto Oswaldo Cruz 2002-10, Vol.97 (7), p.917-940
Hauptverfasser:	Cheever, Allen W, Lenzi, Jane A, Lenzi, Henrique L, Andrade, Zilton A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Chronic Disease Disease Models, Animal experimental models Granuloma - immunology Granuloma - parasitology Granuloma - pathology Liver Cirrhosis - immunology Liver Cirrhosis - parasitology Liver Cirrhosis - pathology Liver Diseases, Parasitic - immunology Liver Diseases, Parasitic - parasitology Liver Diseases, Parasitic - pathology PARASITOLOGY Schistosoma mansoni schistosomiasis Schistosomiasis mansoni - immunology Schistosomiasis mansoni - pathology Species Specificity Th1 Cells - immunology Th2 Cells - immunology TROPICAL MEDICINE
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Zusammenfassung:	Experimental models of Schistosoma mansoni infections in mammals have contributed greatly to our understanding of the pathology and pathogenesis of infection. We consider here hepatic and extrahepatic disease in models of acute and chronic infection. Experimental schistosome infections have also contributed more broadly to our understanding of granulomatous inflammation and our understanding of Th1 versus Th2 related inflammation and particularly to Th2-mediated fibrosis of the liver.
ISSN:	0074-0276 1678-8060 0074-0276 1678-8060
DOI:	10.1590/S0074-02762002000700002