Curcumin encapsulated dual cross linked sodium alginate/montmorillonite polymeric composite beads for controlled drug delivery
The aim of the present work is fabrication of dual cross linked sodium alginate (SA)/montmorillonite (MMT) microbeads as a potential drug vehicle for extended release of curcumin (CUR). The microbeads were prepared using in situ ion-exchange followed by simple ionotropic gelation technique. The deve...
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Veröffentlicht in: | Journal of pharmaceutical analysis 2021-04, Vol.11 (2), p.191-199 |
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Sprache: | eng |
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Zusammenfassung: | The aim of the present work is fabrication of dual cross linked sodium alginate (SA)/montmorillonite (MMT) microbeads as a potential drug vehicle for extended release of curcumin (CUR). The microbeads were prepared using in situ ion-exchange followed by simple ionotropic gelation technique. The developed beads were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD) and scanning electron microscopy (SEM). The effect of MMT on encapsulation efficiency of CUR and intercalation kinetics was investigated. Dynamic swelling study and in vitro release study were investigated in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results suggested that both the swelling and in vitro release studies were influenced by the pH of test media, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into Korsmeyer-Peppas equation.
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•The microbeads prepared using sodium alginate (SA)/montmorillonite (MMT) were found to be potentially good carriers of curcumin (CUR) for extended release of CUR.•The bioavailability of CUR is increased by the usage of MMT in the microbeads, hence making it possible to enhance the anti-tumour activity.•The incorporation of multivalent ions like Mg2+, Ba2+ and Al3+ into calcium alginate matrix modified the swelling property and release rate of bio-active molecules.•The porous nature of the microbeads was based on the size and interaction of the ions namely Mg2+, Ba2+ and Al3+ with alginate. |
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ISSN: | 2095-1779 2214-0883 |
DOI: | 10.1016/j.jpha.2020.07.002 |