Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment

Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early...

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Veröffentlicht in:	Antioxidants 2023-02, Vol.12 (2), p.462
1. Verfasser:	Butterfield, D Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abeta and oxidative stress Activities of daily living Alzheimer's disease Brain Cognition & reasoning Cognition disorders Cognitive ability Dementia Dementia disorders Dogs Free radicals Glucose Homeostasis Hypotheses key metabolic pathways involved in MCI Kinases Laboratories Lipid peroxidation Lipids Metabolism Mutation Neurodegenerative diseases neuronal loss Oxidation Oxidative stress Pathology Pathophysiology Peptides Physiological aspects potential therapeutic strategies for MCI Proteins Proteomics Review Tomography
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Beschreibung
Zusammenfassung:	Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.
ISSN:	2076-3921 2076-3921
DOI:	10.3390/antiox12020462