The Rate of Relapse of Primary Monosymptomatic Nocturnal Enuresis with Desmopressin Treatment in Comparison with Combined Treatment of Desmopressin and Tolterodine in Children Aged 5 to 16 Years

Background: In the process of treating children with primary monosymptomatic nocturnal enuresis (PMNE), the relapse of PMNE after stopping the medicine causes the child to take the medicine for a prolonged time. The purpose of this study is to compare the rate of disease relapse in two groups of PMNE treatment with a combination of desmopressin + tolterodine and desmopressin alone. Materials and Methods: One hundred twenty-three patients of both genders, suffering from nocturnal enuresis, 5-16 years old, were examined in a randomized, single-blind, single-center clinical trial. The first group was given one puff of desmopressin nasal spray and the second group was given one puff of desmopressin nasal spray + 1 mg tolterodine one hour before going to sleep. Data were analyzed using SPSS 21 software and Chi-Square and student t-test (P