Effects of population age structure on parenteral antimicrobial use estimations

Effects of population age structure on parenteral antimicrobial use estimations

Antimicrobial use (AMU) is conventionally reported as unadjusted defined daily doses (DDDs) or population-adjusted DDDs per 1000 inhabitants per day (DID). DID is frequently used to monitor national AMU trends, this metric does not intrinsically take temporal changes in population age structure into...

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Veröffentlicht in:Scientific reports 2023-01, Vol.13 (1), p.840-7, Article 840
Hauptverfasser: Koizumi, Ryuji, Kusama, Yoshiki, Asai, Yusuke, Tsuzuki, Shinya, Aoyagi, Kensuke, Ishikane, Masahiro, Muraki, Yuichi, Ohmagari, Norio
Format: Artikel
Sprache:eng
Schlagworte:
692/308
692/699
692/700
Age
Age composition
Aged
Aged, 80 and over
Aging
Anti-Infective Agents - therapeutic use
Antimicrobial agents
Antimicrobial Stewardship
Child
Data Collection
Databases, Factual
Humanities and Social Sciences
Humans
Japan
multidisciplinary
Older people
Prediction models
Science
Science (multidisciplinary)
Trends
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Zusammenfassung:Antimicrobial use (AMU) is conventionally reported as unadjusted defined daily doses (DDDs) or population-adjusted DDDs per 1000 inhabitants per day (DID). DID is frequently used to monitor national AMU trends, this metric does not intrinsically take temporal changes in population age structure into account. We examined the effects of population age structure on DID estimates of parenteral AMU in Japan, and predicted future trends in DDDs based on population projections. Parenteral AMU data from 2013 to 2018 were acquired from a national claims database. We assessed temporal trends in parenteral AMU by age group (children aged 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-27769-z