Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species

The organic extract of liquid cultures of the marine-derived sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A ( ) and B ( ), together with the previously reported cyclo( -Pro -Phe) ( ) and cyclo( -Pro -Phe) ( ). The structures of compounds - were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds - displayed variable cytotoxic and antimicrobial activities.