Study on Dissolution test and the correlation factors that lead to different Bioavailability of Drugs

The aim of this work is to study the physical and chemical characteristics solubility testing by using three types of drugs which are: (Clopidegrol tablet, Simvastatin tablet, Chlorpromazine tablet). From different sources (France, Jordan, India, Germany, Creek, Syria and Lebanon) according to American standard (U.S.P30) to obtain the results to the primary solubility testing data the result of the significant level comparison to analysis the variation for the test of equal means of the data of solubility as following:1 - The solubility of the French drug is the heights with significant level differences at:A - With a highly significant level (P < 0.01) Compared with the Indian product.B - With a non significant level at ( P > 0.05) Compared with Jordan product.C - A highly significant level at (P < 0.01) according to the solubility of Jordan product by using Simvastatin.2 - The results of significant difference is based on the highest solubility by using Clopidegrol drug at (P < 0.01) compared with the Jordan and with significant level (P < 0.05) compared with Indian drug .3 - Also the result of significant level comparison given high significant level (P < 0.01) between the German product which gives a high significant difference level compared with the Greek product and with un significant level ( P > 0.05) compared with Indian product .4 - Show that their exist a significant difference (P < 0.05) with the highly solubility for the Lebanon product compared with Syrian product by also using chlorpromazine in similarly test for average reading of solubility by using t-test.