Gene expression-based biological test for major depressive disorder: an advanced study

Recently, we could distinguished patients with major depressive disorder (MDD) from nonpsychiatric controls with high accuracy using a panel of five gene expression markers ( , and ) in leukocyte. In the present study, we examined whether this biological test is able to discriminate patients with MD...

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Veröffentlicht in:Neuropsychiatric disease and treatment 2017-01, Vol.13, p.535-541
Hauptverfasser: Watanabe, Shin-Ya, Numata, Shusuke, Iga, Jun-Ichi, Kinoshita, Makoto, Umehara, Hidehiro, Ishii, Kazuo, Ohmori, Tetsuro
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Sprache:eng
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Zusammenfassung:Recently, we could distinguished patients with major depressive disorder (MDD) from nonpsychiatric controls with high accuracy using a panel of five gene expression markers ( , and ) in leukocyte. In the present study, we examined whether this biological test is able to discriminate patients with MDD from those without MDD, including those with schizophrenia and bipolar disorder. We measured messenger ribonucleic acid expression levels of the aforementioned five genes in peripheral leukocytes in 17 patients with schizophrenia and 36 patients with bipolar disorder using quantitative real-time polymerase chain reaction (PCR), and we combined these expression data with our previous expression data of 25 patients with MDD and 25 controls. Subsequently, a linear discriminant function was developed for use in discriminating between patients with MDD and without MDD. This expression panel was able to segregate patients with MDD from those without MDD with a sensitivity and specificity of 64% and 67.9%, respectively. Further research to identify MDD-specific markers is needed to improve the performance of this biological test.
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/ndt.s120038