05.02 HERITABILITY AND INTRAFAMILIAL AGGREGATION OF ARTERIAL CHARACTERISTICS

BackgroundWe investigated in the same subjects, heritability and familial aggregation of various indexes of arterial stiffness and we partitioned the phenotypic correlation between these traits into shared genetic and environmental components.MethodsUsing a family-based random sampling frame, we recruited 204 parents (mean age, 51.7 years) and 290 offspring (29.4 years) from the population in Cracow, Poland (62 families), Hechtel-Eksel, Belgium (36), and Pilsen, the Czech Republic (50). We measured peripheral pulse pressure (PPp) sphygmomanometrically at the brachial artery; central pulse pressure (PPc), the peripheral (PAIx) and central (CAIx) augmentation indexes by tonometry at the radial artery; and aortic pulse wave velocity (PWV) by tonometry or ultrasound. In multivariate-adjusted analyses, we used the ASSOC and PROC GENMOD procedures as implemented in S.A.G.E. and SAS, respectively.ResultsAll traits, with the exception of PPc (P = 0.79) and PWV (P = 0.08), showed significant heritability (P ≤ 0.0001), ranging from 0.37 for PPp to 0.41 for CAIx. The genetic correlation between PWV and the other arterial indexes were significant (ρG≥0.29; P0.29; P