Comparative analysis of global transcriptome, proteome and acetylome in house dust mite‐induced murine allergic asthma model

[...]the murine strains and modelling methods used in literature reports are different from each other3–10 (Table S3). [...]in order to comprehensively analyze the molecular regulation mechanism during allergic asthma and obtain more accurate results, we also performed RNA sequence analysis of the whole lung of the same murine allergic asthma model (Figure S4-S6, Table S4). The acetylated proteins associated with HDM treatment could fall into several groups: metabolic process group (purine ribonucleotide metabolic process and nucleotide metabolic process), cellular component organization group (actin filament organization and cellular component organization), mitochondrial transport group, regulation of endothelial cell proliferation group, positive regulation of cell-substrate adhesion group and cellular response to epidermal growth factor stimulus group (Figure 4A). Transcriptional factors (TFs) can also regulate gene expression through acetylation, and a variety of KATs themselves act as transcription co-activators. [...]we need more research to clarify the acetylation in asthma, such as the acetylation modification of non-coding RNA, the effect of acetylation on the activity of TFs and the presence or changes of specific acetylated lysine sites and its role in asthma. [...]our data are open to the vast number of scientific researchers.