Application of low-dose esketamine combined with dexmedetomidine in anesthesia for elderly patients with percutaneous vertebroplasty

Objective To investigate the effects of low-esmketamine combined with dexmedetomidine on intra-venous analgesia, sedation in elderly patients undergoing percutaneous vertebroplasty (PVP). Methods A total of seventy-two elderly patients aged 70-90 years old who underwent PVP in Beijing Chuiyangliu hospital between March to November 2021 were enrolled in this study. Patients were assigned randomly by a random number table method into controll group (SF-DEX, n=36) and test group (ES-DEX, n=36) for the seddative analgesia anesthesia. All patients were accepted a 0.5 μg/kg dexmedetomidine by pump into venous within 10 min, the other 5 μg sufentanil was gived venously and then 0.5 μg/(kg·h) dexmedetomidine by pump in SF-DEX. 0.1 mg/kg esketamine was gived venously and then 0.1 mg/(kg·h) by pump in EK-DEX. The changes of circulatory indexes systolis arterial pressure(SAP),diastolis arterial pressure(DAP),mean arterial pressure(MAP),heart rate(HR), saturated oxygen (SpO2), BIS indexes, pain intensity (VAS), Ramsay sc